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MS9715

CAT: 0013-GTR19178361Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19178361Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS9715 (MS-9715) is a NSD3-targeting PROTAC designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand.MS9715 achieves effective and specific targeting of NSD3 and associated cMyc node in tumor cells.MS9715 effectively suppresses growth of NSD3-dependent hematological cancer cells.MS 9715 effectively suppresses NSD3-and cMyc-associated gene expression programs, resembling effects of the CRISPR-Cas9-mediated knockout of NSD3.
Purity
>98%
Smiles
O=C ([C@H]1N (C ([C@@H] (NC (CCCCCCCCNC (CCCNCC2=CC (C) =C (C3=C (C4=CC=NC5=CC (F) =CC=C45) N (C) C=N3) C (C) =C2) =O) =O) C (C) (C) C) =O) C[C@H] (O) C1) N[C@H] (C6=CC=C (C7=C (C) N=CS7) C=C6) C
Molecular Formula
C58H74FN9O5S
Molecular Weight
1028.346
Notes
For research use only.

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MBS5821277MS9715
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