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MMV030084

CAT: 0013-GTR19178352-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19178352-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMV030084 (MMV-030084) is a potent, specific P. falciparum cGMP-dependent protein kinase (PKG) inhibitor (Kdapp=9-16 nM), inhibits invasion of P. berghei ANKA parasites into HepG2 liver cells with IC50 of 199 nM.MMV030084 potently inhibits hepatocyte invasion by Plasmodium sporozoites, merozoite egress from asexual blood stage schizonts, and male gamete exflagellation, shows potent activity against liver, asexual, and sexual blood stage development.MMV030084 showed an IC50 of 109 nM against the drug-sensitive 3D7-A10 line, and an IC50 of 120 nM against multidrug-resistant Dd2-B2 parasites in a 72-h growth inhibition assay against Pf ABS parasites.MMV030084 inhibited male gamete exflagellation at an IC50 of 141 nM when gametocytes were stimulated to develop into male gametes.MMV030084 is a promising Plasmodium PKG-targeting chemotype.
CAS Number
342434-07-5
Purity
>98%
Smiles
C1 (C2=C (C3C=CC (Cl) =C (O) C=3) NC (=N2) C (C) (C) CN) =CC=NC=C1
Molecular Formula
C18H19CLN4O
Molecular Weight
342.82
Notes
For research use only.

Alternative Products

CatalogName
T202369-01MMV030084

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