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W-54011

CAT: 0013-GTR19177856-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177856-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
W-54011 is a potent, non-peptide antagonist of the C5a receptor (C5aR1) . It effectively blocks C5a binding (Ki = 2.2 nM) and inhibits downstream functional responses in human neutrophils, including calcium mobilization, chemotaxis, and ROS generation. This compound is a valuable research tool for studying complement-mediated inflammation in both in vitro and in vivo models.
CAS Number
405098-33-1
Product Name Alternative
Ca2+, C5a, Ca2+ mobilization, , anaphylatoxin, Complement System, ComplementSystem, complement 5a receptor (C5aR), chemotaxis, Chemotaxis, orally, mobilization, neutrophils, inhibit, inflammatory, Inhibitor, W 54011, W54011, W-54011, Reactive Oxygen Species, ROS
Field of Research
Immunology & Inflammation, Metabolism Research, Signal Transduction
Purity
95.62% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.06 mM) ; DMSO:28 mg/mL (56.79 mM)
Smiles
Cl.COc1ccc2CCCC (C (=O) N (Cc3ccc (cc3) N (C) C) c3ccc (cc3) C (C) C) c2c1
Molecular Formula
C30H37ClN2O2
Molecular Weight
493.08
Storage Conditions
-20°C
Notes
For research use only.

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