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Wnt pathway activator 1

CAT: 0013-GTR19177852-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177852-02Size:5 mg
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Description
Wnt pathway activator 1 is a highly potent small molecule Wnt/β-catenin signaling agonist, exhibiting an IC50 of 28-29 nM. It is utilized in research exploring hair follicle regeneration and has shown potential in preclinical models for androgenetic alopecia. This compound is a valuable tool for both in vitro and in vivo studies of Wnt pathway biology.
CAS Number
1360540-81-3
Product Name Alternative
Beta-catenin, betacatenin, bcatenin, inhibit, Inhibitor, βcatenin, Wnt/β-catenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt pathway activator 1, Wnt pathway activator1, Wnt pathway activator-1
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
99.93% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (8.44 mM) ; DMSO:60 mg/mL (202.48 mM)
Smiles
O=C (CCC (=O) c1ccc2OCCOc2c1) c1ccccc1
Molecular Formula
C18H16O4
Molecular Weight
296.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Dalosirvat

Dalosirvat is under investigation in clinical trial NCT03742518 (A Study Evaluating the Efficacy and Safety of SM04554 Topical Solution in Male Subjects With Androgenetic Alopecia).

CAS Number1360540-81-3
PubChem CID56837361
IUPAC Name1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-phenylbutane-1,4-dione
Molecular FormulaC18H16O4
Molecular Weight296.3
XLogP1.8
Topological Polar Surface Area52.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count22
Formal Charge0
Complexity400
SMILES
C1COC2=C(O1)C=CC(=C2)C(=O)CCC(=O)C3=CC=CC=C3
InChI
InChI=1S/C18H16O4/c19-15(13-4-2-1-3-5-13)7-8-16(20)14-6-9-17-18(12-14)22-11-10-21-17/h1-6,9,12H,7-8,10-11H2
InChIKey
AOCDRSSVFUCURK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dalosirvat
CAS: 1360540-81-3
CID: 56837361
Formula: C18H16O4
MW: 296.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.3
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass296.10485899
Monoisotopic Mass296.10485899
Topological Polar Surface Area52.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity400
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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