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Baclofen

CAT: 0013-GTR19177913-04Size: 5 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19177913-04Size:5 g
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Description
Baclofen (Lioresal) is a chlorophenyl derivative and a selective GABA-B receptor agonist used to alleviate muscle spasticity. It is widely applied in neuroscience research to study inhibitory neurotransmission in models of spinal cord injury, multiple sclerosis, and in both in vivo and in vitro experimental systems.
CAS Number
1134-47-0
Product Name Alternative
Spasticity, γ-aminobutyric acid, γ-Aminobutyric acid Receptor, Lioresal, Lipophilic, inhibit, orally, Inhibitor, GABAReceptor, GABABR, GABAR, Gamma-aminobutyric acid Receptor, GABA Receptor, GABA, Baclofen, blood brain barrier, bbb
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
H2O:2.5 mM; DMSO:Insoluble
Smiles
NCC (CC (O) =O) C1=CC=C (Cl) C=C1
Molecular Formula
C10H12ClNO2
Molecular Weight
213.66
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Baclofen

Baclofen is a monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant. It has a role as a central nervous system depressant, a muscle relaxant and a GABA agonist. It is a monocarboxylic acid, a gamma-amino acid, a primary amino compound and a member of monochlorobenzenes. It is a tautomer of a baclofen zwitterion.

CAS Number1134-47-0
PubChem CID2284
IUPAC Name4-amino-3-(4-chlorophenyl)butanoic acid
Molecular FormulaC10H12ClNO2
Molecular Weight213.66
XLogP-1
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count14
Formal Charge0
Complexity191
SMILES
C1=CC(=CC=C1C(CC(=O)O)CN)Cl
InChI
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey
KPYSYYIEGFHWSV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Baclofen
CAS: 1134-47-0
CID: 2284
Formula: C10H12ClNO2
MW: 213.66
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight213.66
XLogP3-1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass213.0556563
Monoisotopic Mass213.0556563
Topological Polar Surface Area63.3 Ų
Heavy Atom Count14
Formal Charge0
Complexity191
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C4051-5000(±)-Baclofen
RM-B011200-01Baclofen
sc-200464(±) -Baclofen

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