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Sulfasalazine

CAT: 0013-GTR19177473-02Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19177473-02Size:1 g
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Description
Sulfasalazine is a prodrug derived from salicylic acid that exhibits affinity for elastin-rich tissues. It is widely used in research to study ferroptosis and inflammatory pathways, as it inhibits NF-κB, TGF-β, and COX-2 in both cellular and animal models of disease.
CAS Number
599-79-1
Product Name Alternative
COX-2, COX-1, Apoptosis, Antibiotic, Bacterial, Azulfidine, Autophagy, NSC 667219, inhibit, Nuclear factor-κB, Nuclear factor-kappaB, NSC667219, NSC-667219, NF-κB, NFκB, NFkB, NF-kB, Ferroptosis, Inhibitor, Sulfasalazine
Field of Research
Cell Biology, Immunology & Inflammation
Purity
>98%
Bioactivity
Anti-inflammatory / antibiotic
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) .
Smiles
OC (=O) C1=CC (=CC=C1O) \N=N\C1=CC=C (C=C1) S (=O) (=O) NC1=CC=CC=N1
Molecular Formula
C18H14N4O5S
Molecular Weight
398.39
Storage Conditions
RT
Notes
For research use only.
Other Product Names
2-Hydroxy-5-{{4-[ (2-pyridinylamino) sulfonyl]phenyl}azo}benzoic acid

Chemical Information

Sulfasalazine

Sulfasalazine (salicylazosulfapyridine) can cause cancer according to The National Toxicology Program. It can cause male reproductive toxicity according to state or federal government labeling requirements.

CAS Number599-79-1
PubChem CID5339
IUPAC Name2-hydroxy-5-[[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl]benzoic acid
Molecular FormulaC18H14N4O5S
Molecular Weight398.4
XLogP-0.7
Topological Polar Surface Area150
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity657
SMILES
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
InChI
InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)
InChIKey
NCEXYHBECQHGNR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sulfasalazine
CAS: 599-79-1
CID: 5339
Formula: C18H14N4O5S
MW: 398.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.4
XLogP3-0.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass398.06849073
Monoisotopic Mass398.06849073
Topological Polar Surface Area150 Ų
Heavy Atom Count28
Formal Charge0
Complexity657
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
A5770-5.1Sulfasalazine

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