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GPI-1046

CAT: 0013-GTR19177300-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177300-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPI-1046 is a non-antibiotic immunophilin ligand that reduces ethanol consumption in preclinical models. Its mechanism involves the upregulation of the GLT1 (EAAT2) glutamate transporter in key brain regions like the prefrontal cortex and nucleus accumbens core, making it a valuable research tool for studying addiction neurobiology.
CAS Number
186452-09-5
Product Name Alternative
Inhibit, HIV, HIV Protease, HIVProtease, Inhibitor, GLT1, GPI-1046, GPI1046, GPI 1046, Human immunodeficiency virus, FK506-binding protein, FKBP
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Protein Biochemistry
Purity
99.69% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.16 mM) ; DMSO:100 mg/mL (277.43 mM)
Smiles
C (C (C (CC) (C) C) =O) (=O) N1[C@H] (C (OCCCC=2C=CC=NC2) =O) CCC1
Molecular Formula
C20H28N2O4
Molecular Weight
360.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gpi-1046

structure given in first source

CAS Number186452-09-5
PubChem CID445501
IUPAC Name3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate
Molecular FormulaC20H28N2O4
Molecular Weight360.4
XLogP3.1
Topological Polar Surface Area76.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count26
Formal Charge0
Complexity518
SMILES
CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)OCCCC2=CN=CC=C2
InChI
InChI=1S/C20H28N2O4/c1-4-20(2,3)17(23)18(24)22-12-6-10-16(22)19(25)26-13-7-9-15-8-5-11-21-14-15/h5,8,11,14,16H,4,6-7,9-10,12-13H2,1-3H3/t16-/m0/s1
InChIKey
OQAHHWOPVDDWHD-INIZCTEOSA-N
Chemical Structure
2D Structure
2D structure of Gpi-1046
CAS: 186452-09-5
CID: 445501
Formula: C20H28N2O4
MW: 360.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight360.4
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass360.20490738
Monoisotopic Mass360.20490738
Topological Polar Surface Area76.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity518
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA1909-5.1GPI-1046
A13015-50GPI-1046 50mg
A13015-25GPI-1046 25mg
A13015-10GPI-1046 10mg
A13015-5GPI-1046 5mg
A13015-2GPI-1046 2mg
A13015-1GPI-1046 1mg
A13015-100GPI-1046 100mg
A13015-10mM-DGPI-1046 10mM * 1mL in DMSO
TQ0123MC 1046

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