Products for Research Use Only
RegisterLogin

GSK-3β inhibitor 1

CAT: 0013-GTR19177293-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19177293-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
This potent and selective GSK-3β inhibitor exhibits an IC50 of 4.9 nM. It is a valuable research tool for studying glycogen metabolism, Wnt/β-catenin signaling, and diabetes mechanisms in cellular models, and has demonstrated significant anti-hyperglycemic effects in preclinical in vivo studies.
CAS Number
187325-53-7
Product Name Alternative
Glycogen synthase kinase-3, Glycogen synthase kinase 3, GSK-3β inhibitor 1, GSK 3β inhibitor 1, GSK-3, GSK3, GSK-3β, GSK3β inhibitor 1, GSK-3beta inhibitor 1, GSK-3b inhibitor 1, Inhibitor, inhibit
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.08% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9 mM) ; DMSO:30 mg/mL (134.99 mM)
Smiles
C (=C\1/C=2C (NC1=O) =CC=CC2) \C3=CC=CC=N3
Molecular Formula
C14H10N2O
Molecular Weight
222.24
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(3Z)-3-(pyridin-2-ylmethylidene)-1H-indol-2-one
CAS Number187325-53-7
PubChem CID5796182
IUPAC Name(3Z)-3-(pyridin-2-ylmethylidene)-1H-indol-2-one
Molecular FormulaC14H10N2O
Molecular Weight222.24
XLogP1.9
Topological Polar Surface Area42
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity337
SMILES
C1=CC=C2C(=C1)/C(=C/C3=CC=CC=N3)/C(=O)N2
InChI
InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
InChIKey
YKQONSWBHGBDSB-XFXZXTDPSA-N
Chemical Structure
2D Structure
2D structure of (3Z)-3-(pyridin-2-ylmethylidene)-1H-indol-2-one
CAS: 187325-53-7
CID: 5796182
Formula: C14H10N2O
MW: 222.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight222.24
XLogP31.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass222.079312947
Monoisotopic Mass222.079312947
Topological Polar Surface Area42 Ų
Heavy Atom Count17
Formal Charge0
Complexity337
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19192053-01GSK-3β inhibitor 3
GTR19244108-01GSK-3β inhibitor 3
GTR19243640-01GSK-3 inhibitor 3
GTR19213615-01GSK-3 inhibitor 3
GTR19192052-01GSK-3β inhibitor 8
GTR19184745-01GSK-3β inhibitor 7
GTR19257930-01GSK-3β inhibitor 27
GTR19250166-01GSK-3β inhibitor 25
GTR19243958-01GSK-3β inhibitor 12
GTR19243641-01GSK-3 inhibitor 4

Alternative Products

CatalogName
M36857-01GSK-3 inhibitor 3
HY-141480-01GSK-3β inhibitor 3
BUP06965-01GSK-3ß inhibitor 3
TBI1400-25MG6BIO, GSK-3 inhibitor
T209986-01GSK-3β inhibitor 16
T205441-01GSK-3β inhibitor 26
T204492-01GSK-3β inhibitor 24
T200457-01GSK-3β inhibitor 20
HY-148133-01GSK-3β inhibitor 12
HY-126201GSK-3 inhibitor 7

Popular Products