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Sunitinib

CAT: 0013-GTR19177130-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177130-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sunitinib (SU11248) is a multi-targeted receptor tyrosine kinase inhibitor with potent activity against VEGFR2 and PDGFRβ (IC50=80/2 nM) . It exhibits antitumor effects and is used in research on renal cell carcinoma and gastrointestinal stromal tumors, supported by both in vitro and in vivo studies.
CAS Number
557795-19-4
Product Name Alternative
Apoptosis, Autophagy, cKit, c-Kit, inhibit, IRE1, Platelet-derived growth factor receptor, Mitophagy, Mitochondrial Autophagy, Inositol requiring enzyme 1, Inhibitor, FLT3, SU 11248, SU11248, SU-11248, Sunitinib, PDGFR, PDGFRβ, VEGFR2, VEGFR, Vascular endothelial growth factor receptor
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.25 mg/mL (3.14 mM) ; DMSO:25 mg/mL (62.74 mM)
Smiles
C (=C\1/C=2C (NC1=O) =CC=C (F) C2) \C3=C (C) C (C (NCCN (CC) CC) =O) =C (C) N3
Molecular Formula
C22H27FN4O2
Molecular Weight
398.47
References & Citations
Ryan Tsz-Hei Tse 1, Christine Yim-Ping Wong 1, Xiaofan Ding 2, Carol Ka-Lo Cheng 1, Chit Chow 3, Ronald Cheong-Kin Chan 3, Joshua Hoi-Yan Ng 4, Victor Wai-Lun Tang 4, Peter Ka-Fung Chiu 1, Jeremy Yuen-Chun Teoh 1, Nathalie Wong 2, Ka-Fai To 3, Chi-Fai Ng The establishment of kidney cancer organoid line in drug testing Cancer Med, (2024)
Pubmed id
38923304
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Sunitinib

Sunitinib is a member of pyrroles and a monocarboxylic acid amide. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an immunomodulator, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a neuroprotective agent and a vascular endothelial growth factor receptor antagonist. It is functionally related to a 3-methyleneoxindole.

CAS Number557795-19-4
PubChem CID5329102
IUPAC NameN-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Molecular FormulaC22H27FN4O2
Molecular Weight398.5
XLogP2.6
Topological Polar Surface Area77.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Heavy Atom Count29
Formal Charge0
Complexity636
SMILES
CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C
InChI
InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
InChIKey
WINHZLLDWRZWRT-ATVHPVEESA-N
Chemical Structure
2D Structure
2D structure of Sunitinib
CAS: 557795-19-4
CID: 5329102
Formula: C22H27FN4O2
MW: 398.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.5
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass398.21180428
Monoisotopic Mass398.21180428
Topological Polar Surface Area77.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity636
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1045-500Sunitinib
A8255-2000Sunitinib malate
CS-O-10804Sunitinib-d4

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