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Dexamethasone

CAT: 0013-GTR19176893-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19176893-01Size:1 g
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Description
Dexamethasone is a potent synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties, acting as a glucocorticoid receptor agonist. It is widely used in research to model conditions like depression and muscle atrophy in vivo, and to study cytokine modulation and autophagy in cellular experiments. Its mechanisms include inhibiting inflammatory exosome release and suppressing LPS-induced macrophage activation.
CAS Number
50-02-2
Product Name Alternative
Dexamethasone, Complement System, ComplementSystem, CD18, CD62L, CD11b, ADC Cytotoxin, ADCCytotoxin, Autophagy, Antibiotic, Bacterial, MK125, MK-125, neutrophils, NSC34521, NSC-34521, Mitophagy, Mitochondrial Autophagy, MK 125, ILReceptor, monocytes, IL Receptor, IL receptor, inhibit, NSC 34521, glucocorticoid, GlucocorticoidReceptor, Glucocorticoid Receptor, Inhibitor, Hexadecadrol, Prednisolone F, receptor, SARSCoV, SARS-CoV, SARS coronavirus
Field of Research
Cell Biology, Immunology & Inflammation, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Apoptosis inducing glucocorticoid
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) .
Smiles
F[C@@]12[C@] ([C@]3 ([C@] (C) (C[C@@H]1O) [C@] (C (CO) =O) (O) [C@H] (C) C3) [H]) (CCC=4[C@]2 (C) C=CC (=O) C4) [H]
Molecular Formula
C22H29FO5
Molecular Weight
392.5
Storage Conditions
RT
Notes
For research use only.
Other Product Names
(11β,16α) -9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Chemical Information

Dexamethasone

Dexamethasone is a fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids. It has a role as an anti-inflammatory drug, an antineoplastic agent, a xenobiotic, an immunosuppressive agent, an adrenergic agent, an antiemetic and an environmental contaminant. It is a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid and a 3-oxo-Delta(1),Delta(4)-steroid. It derives from a hydride of a pregnane.

CAS Number50-02-2
PubChem CID5743
IUPAC Name(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Molecular FormulaC22H29FO5
Molecular Weight392.5
XLogP1.9
Topological Polar Surface Area94.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count28
Formal Charge0
Complexity805
SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
InChI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey
UREBDLICKHMUKA-CXSFZGCWSA-N
Chemical Structure
2D Structure
2D structure of Dexamethasone
CAS: 50-02-2
CID: 5743
Formula: C22H29FO5
MW: 392.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight392.5
XLogP31.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass392.19990218
Monoisotopic Mass392.19990218
Topological Polar Surface Area94.8 Ų
Heavy Atom Count28
Formal Charge0
Complexity805
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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