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FGFR1/DDR2 inhibitor 1

CAT: 0013-GTR19176710-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176710-01Size:1 mg
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Description
This small molecule is a potent dual inhibitor of DDR2 and FGFR1, exhibiting IC50 values of 3.2 nM and 31.1 nM, respectively. It is a valuable research tool for studying kinase signaling in cancer models, including leukemia cell lines like KG-1, in both in vitro and in vivo experimental settings.
CAS Number
2308497-58-5
Product Name Alternative
Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor, DiscoidinDomainReceptor (DDR), cells, DDR, DDR2, Fibroblast growth factor receptor, FGFR, FGFR1, FGFR1/DDR2 inhibitor 1, FGFR-1/DDR2 inhibitor 1, NCI-H1581, NCI-H2286, Nude, mice, inhibit, Inhibitor, KG-1, phosphorylation, SCID, tumor
Field of Research
Cardiovascular Research, Musculoskeletal & Connective Tissue Research; Pharmacology & Drug Discovery, Signal Transduction
Purity
99.14% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (6.58 mM) ; DMSO:250 mg/mL (498.5 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
Cc1ccc (cc1-c1ccc2c (n[nH]c2c1) -c1cnn (c1) C1CC1) C (=O) Nc1cccc (c1) C (F) (F) F
Molecular Formula
C28H22F3N5O
Molecular Weight
501.5
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

FGFR1/DDR2 inhibitor 1
CAS Number2308497-58-5
PubChem CID138454761
IUPAC Name3-[3-(1-cyclopropylpyrazol-4-yl)-1H-indazol-6-yl]-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamide
Molecular FormulaC28H22F3N5O
Molecular Weight501.5
XLogP5.7
Topological Polar Surface Area75.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count37
Formal Charge0
Complexity822
SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC4=C(C=C3)C(=NN4)C5=CN(N=C5)C6CC6
InChI
InChI=1S/C28H22F3N5O/c1-16-5-6-18(27(37)33-21-4-2-3-20(13-21)28(29,30)31)11-24(16)17-7-10-23-25(12-17)34-35-26(23)19-14-32-36(15-19)22-8-9-22/h2-7,10-15,22H,8-9H2,1H3,(H,33,37)(H,34,35)
InChIKey
ZEOWTGPWHLSLOG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of FGFR1/DDR2 inhibitor 1
CAS: 2308497-58-5
CID: 138454761
Formula: C28H22F3N5O
MW: 501.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight501.5
XLogP35.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass501.17764483
Monoisotopic Mass501.17764483
Topological Polar Surface Area75.6 Ų
Heavy Atom Count37
Formal Charge0
Complexity822
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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BUP05309-01FGFR1/DDR2 inhibitor 1
A18716-100FGFR1/DDR2 inhibitor 1 100mg
A18716-25FGFR1/DDR2 inhibitor 1 25mg
A18716-50FGFR1/DDR2 inhibitor 1 50mg
A18716-5FGFR1/DDR2 inhibitor 1 5mg
A18716-10FGFR1/DDR2 inhibitor 1 10mg
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