Eplerenone

CAT: 0013-GTR19176486-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19176486-01Size:2 mg

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Description

Eplerenone (CGP 30083) is a selective aldosterone antagonist used as an antihypertensive and cardioprotective agent. It is widely applied in cardiovascular research, including in vitro receptor binding assays and in vivo models of hypertension and heart failure.

CAS Number

107724-20-9

Product Name Alternative

Aldosterone, cardiovascular (CV), atherosclerosis, CGP 30083, CGP30083, CGP-30083, chronic systolic heart failure (HF), Endogenous Metabolite, Inhibitor, hypertension, Glucocorticoid Receptor, GlucocorticoidReceptor, Eplerenone, Epoxymexrenone, Mineralocorticoid Receptor, MRA, inhibit, specific, SC 66110, SC66110, SC-66110

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Purity

≥98% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.41 mM) ; DMSO:7.14 mg/mL (17.23 mM)

Smiles

C[C@@]12[C@]34[C@] ([C@]5 ([C@] (C) (C[C@]3 (O4) [H]) [C@@]6 (CC5) CCC (=O) O6) [H]) ([C@H] (C (OC) =O) CC1=CC (=O) CC2) [H]

Molecular Formula

C24H30O6

Molecular Weight

414.49

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Eplerenone

Eplerenone is an epoxy steroid, a methyl ester, a gamma-lactone, an oxaspiro compound, an organic heteropentacyclic compound, a steroid acid ester and a 3-oxo-Delta(4) steroid. It has a role as an antihypertensive agent and an aldosterone antagonist. It derives from a hydride of a pregnane.

CAS Number	107724-20-9
PubChem CID	443872
IUPAC Name	methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate
Molecular Formula	C24H30O6
Molecular Weight	414.5
XLogP	1.4
Topological Polar Surface Area	82.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Heavy Atom Count	30
Formal Charge	0
Complexity	907

SMILES

C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC

InChI

InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChIKey

JUKPWJGBANNWMW-VWBFHTRKSA-N

Chemical Structure

2D Structure

CAS: 107724-20-9

CID: 443872

Formula: C24H30O6

MW: 414.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	414.5
XLogP3	1.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	414.20423867
Monoisotopic Mass	414.20423867
Topological Polar Surface Area	82.2 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	907
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
sc-203943	Eplerenone
RM-E181400-01	(+) -Eplerenone

Eplerenone

Chemical Information

Alternative Products

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