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Promazine hydrochloride

CAT: 0013-GTR19176014-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19176014-01Size:1 ml x 10 mM (in DMSO)
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Description
Promazine hydrochloride is a phenothiazine derivative with antiemetic and sedative properties, exhibiting weaker antipsychotic activity than chlorpromazine. It is utilized in research for studying disturbed behavior models in vivo and dopaminergic receptor interactions in vitro.
CAS Number
53-60-1
Product Name Alternative
Dopamine Receptor, Dopamine, DopamineReceptor, Berophen, Ampazine, antipsychotic, Adrenergic Receptor, AdrenergicReceptor, 5HT Receptor, 5-HT, 5HTReceptor, inhibit, Inhibitor, norepinephrine, mAChR, Sinophenin hydrochloride, Sinophenin Hydrochloride, phenothiazin, Promazine, Promazine hydrochloride, Promazine Hydrochloride, Romtiazin, Romtiazin hydrochloride, Romtiazin Hydrochloride, transporter
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.74% (May vary between batches)
Solubility
DMSO:58 mg/mL (180.75 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.23 mM)
Smiles
Cl.CN (C) CCCN1c2ccccc2Sc2ccccc12
Molecular Formula
C17H21ClN2S
Molecular Weight
320.88
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Promazine Hydrochloride

Promazine Hydrochloride is the hydrochloride salt form of promazine, a phenothiazine derivative with antipsychotic and antiemetic properties. Promazine hydrochloride blocks postsynaptic dopamine receptors D1 and D2 in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks alpha-adrenergic receptors and exhibits strong anticholinergic activity.

CAS Number53-60-1
PubChem CID5887
IUPAC NameN,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride
Molecular FormulaC17H21ClN2S
Molecular Weight320.9
Topological Polar Surface Area31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity285
SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
InChI
InChI=1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
InChIKey
JIVSXRLRGOICGA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Promazine Hydrochloride
CAS: 53-60-1
CID: 5887
Formula: C17H21ClN2S
MW: 320.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass320.1113975
Monoisotopic Mass320.1113975
Topological Polar Surface Area31.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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