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UT-34

CAT: 0013-GTR19175656-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175656-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UT-34 is a potent, orally bioavailable pan-androgen receptor antagonist and degrader effective against wild-type and mutant (F876L, W741L) AR. It demonstrates anti-tumor activity in prostate cancer models, making it a valuable research tool for investigating AR signaling and therapeutic resistance in both in vitro and in vivo studies.
CAS Number
2168525-92-4
Product Name Alternative
Degrader, cancer, ARVs, AndrogenReceptor, Androgen Receptor, androgen receptor, FKBP5, F876L AR, function-1, enzalutamide, ligand-binding, Inhibitor, inhibit, ubiquitin, UT 34, UT34, UT-34, W741L AR, proteasome, prostate, Wild-type AR
Field of Research
Metabolism Research
Purity
98.10% (May vary between batches)
Solubility
DMSO:71 mg/mL (199.29 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.61 mM)
Smiles
C[C@] (O) (Cn1cc (F) cn1) C (=O) Nc1ccc (C#N) c (c1) C (F) (F) F
Molecular Formula
C15H12F4N4O2
Molecular Weight
356.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-fluoro-1H-pyrazol-1-yl)-2-hydroxy-2-methylpropanamide
CAS Number2168525-92-4
PubChem CID132214622
IUPAC Name(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluoropyrazol-1-yl)-2-hydroxy-2-methylpropanamide
Molecular FormulaC15H12F4N4O2
Molecular Weight356.27
XLogP1.3
Topological Polar Surface Area90.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity549
SMILES
C[C@](CN1C=C(C=N1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
InChI
InChI=1S/C15H12F4N4O2/c1-14(25,8-23-7-10(16)6-21-23)13(24)22-11-3-2-9(5-20)12(4-11)15(17,18)19/h2-4,6-7,25H,8H2,1H3,(H,22,24)/t14-/m0/s1
InChIKey
YDRMSDHDYRAUBR-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-fluoro-1H-pyrazol-1-yl)-2-hydroxy-2-methylpropanamide
CAS: 2168525-92-4
CID: 132214622
Formula: C15H12F4N4O2
MW: 356.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight356.27
XLogP31.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass356.08963829
Monoisotopic Mass356.08963829
Topological Polar Surface Area90.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity549
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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