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RA190

CAT: 0013-GTR19176434-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176434-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RA190 is a proteasome inhibitor that acts by covalently modifying cysteine 88 on the ubiquitin receptor RPN13. This mechanism disrupts protein degradation, making it a valuable tool for studying proteasome biology, cancer research, and apoptosis in both cellular and animal models.
CAS Number
1617495-03-0
Product Name Alternative
Inhibit, Inhibitor, HeLa cell, Proteasome, RA 190, RA190, RA-190
Field of Research
Protein Biochemistry
Purity
97.69% (May vary between batches)
Solubility
DMSO:235 mg/mL (393.79 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.53 mM)
Smiles
Cl.N[C@@H] (Cc1ccccc1) C (=O) N1C\C (=C\c2ccc (Cl) c (Cl) c2) C (=O) \C (C1) =C/c1ccc (Cl) c (Cl) c1
Molecular Formula
C28H23Cl5N2O2
Molecular Weight
596.76
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(L-phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one hydrochloride
CAS Number1617495-03-0
PubChem CID126843229
IUPAC Name(3Z,5Z)-1-[(2S)-2-amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one;hydrochloride
Molecular FormulaC28H23Cl5N2O2
Molecular Weight596.8
Topological Polar Surface Area63.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count37
Formal Charge0
Complexity808
SMILES
C\1N(C/C(=C/C2=CC(=C(C=C2)Cl)Cl)/C(=O)/C1=C\C3=CC(=C(C=C3)Cl)Cl)C(=O)[C@@H](N)CC4=CC=CC=C4.Cl
InChI
InChI=1S/C28H22Cl4N2O2.ClH/c29-22-8-6-18(12-24(22)31)10-20-15-34(28(36)26(33)14-17-4-2-1-3-5-17)16-21(27(20)35)11-19-7-9-23(30)25(32)13-19;/h1-13,26H,14-16,33H2;1H/b20-10-,21-11-;/t26-;/m0./s1
InChIKey
UMWXLEVUBFNYIK-VCCJZKHWSA-N
Chemical Structure
2D Structure
2D structure of 1-(L-phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one hydrochloride
CAS: 1617495-03-0
CID: 126843229
Formula: C28H23Cl5N2O2
MW: 596.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight596.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass596.017266
Monoisotopic Mass594.020216
Topological Polar Surface Area63.4 Ų
Heavy Atom Count37
Formal Charge0
Complexity808
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8284-50RA190
HY-100739RRA190 (Standard)
A12287-1RA190 1mg
533301RA190 HCl
A12287-50RA190 50mg
A12287-100RA190 100mg
A12287-25RA190 25mg
A12287-10RA190 10mg
A12287-5RA190 5mg
A12287-10mM-DRA190 10mM * 1mL in DMSO

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