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TLR1

CAT: 0013-GTR19175537-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175537-05Size:25 mg
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Description
TLR1 is a cell-permeable synthetic peptide that mimics the TIR domain/BB-loop, functioning as a potent inhibitor of IL-1 receptor signaling. This tool compound is widely used in vitro and in vivo to study inflammatory pathways, NLRP3 inflammasome activation, and interleukin-mediated immune responses.
CAS Number
566914-00-9
Product Name Alternative
Inhibitor, inhibit, MyD88, TLR 1, TLR-1, TLR1
Field of Research
Immunology & Inflammation
Purity
98.51% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.61 mM) ; DMSO:30 mg/mL (99.2 mM)
Smiles
C ([C@@H] (NC (CCC1=CC=CC=C1) =O) [C@@H] (C) C) (=O) N2CCCC2
Molecular Formula
C18H26N2O2
Molecular Weight
302.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

IL-1R Antagonist
CAS Number566914-00-9
PubChem CID10447660
IUPAC NameN-[(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide
Molecular FormulaC18H26N2O2
Molecular Weight302.4
XLogP2.8
Topological Polar Surface Area49.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity369
SMILES
CC(C)[C@@H](C(=O)N1CCCC1)NC(=O)CCC2=CC=CC=C2
InChI
InChI=1S/C18H26N2O2/c1-14(2)17(18(22)20-12-6-7-13-20)19-16(21)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,17H,6-7,10-13H2,1-2H3,(H,19,21)/t17-/m0/s1
InChIKey
DAZSWUUAFHBCGE-KRWDZBQOSA-N
Chemical Structure
2D Structure
2D structure of IL-1R Antagonist
CAS: 566914-00-9
CID: 10447660
Formula: C18H26N2O2
MW: 302.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight302.4
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass302.199428076
Monoisotopic Mass302.199428076
Topological Polar Surface Area49.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity369
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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