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CIQ

CAT: 0013-GTR19175439-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175439-02Size:5 mg
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Description
CIQ is a small molecule that selectively potentiates NMDA receptors incorporating the NR2C or NR2D subunit, with EC50 values of 2.7 μM and 2.8 μM, respectively. It serves as a valuable research tool for investigating the specific roles of these receptor subtypes in synaptic plasticity, neurological disorders, and related in vitro and in vivo models.
CAS Number
486427-17-2
Product Name Alternative
CIQ, inhibit, Ionotropic glutamate receptors, Inhibitor, NMDA, iGluR
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.47% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.27 mM) ; DMSO:50 mg/mL (106.85 mM) ; H2O:insoluble
Smiles
COc1ccc (OCC2N (CCc3cc (OC) c (OC) cc23) C (=O) c2cccc (Cl) c2) cc1
Molecular Formula
C26H26ClNO5
Molecular Weight
467.94
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(3-chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

a positive modulator of GluN2C/GluN2D subunit-selective NMDA receptor

CAS Number486427-17-2
PubChem CID4231127
IUPAC Name(3-chlorophenyl)-[6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone
Molecular FormulaC26H26ClNO5
Molecular Weight467.9
XLogP5.2
Topological Polar Surface Area57.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity628
SMILES
COC1=CC=C(C=C1)OCC2C3=CC(=C(C=C3CCN2C(=O)C4=CC(=CC=C4)Cl)OC)OC
InChI
InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
InChIKey
VYMILMYEENZHAR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (3-chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS: 486427-17-2
CID: 4231127
Formula: C26H26ClNO5
MW: 467.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight467.9
XLogP35.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass467.1499506
Monoisotopic Mass467.1499506
Topological Polar Surface Area57.2 Ų
Heavy Atom Count33
Formal Charge0
Complexity628
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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