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Curcumin

CAT: 0013-GTR19175364-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19175364-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Curcumin (Natural Yellow 3) is a specific p300/CREB histone acetyltransferase inhibitor (IC50=25 μM) . This polyphenol exhibits antitumor, anti-inflammatory, and antioxidant activities, making it a valuable tool for epigenetic, cancer, and inflammation research in both cellular and animal models.
CAS Number
458-37-7
Product Name Alternative
Diferuloylmethane, Curcumin, Autophagy, p300 histone acetylatransferase, Mitophagy, Mitochondrial Autophagy, Natural Yellow 3, Natural Yellow3, Natural Yellow-3, inhibit, Influenza Virus, InfluenzaVirus, Indian Saffron, Keap1-Nrf2, KEAP1-Nrf2, HAT, HATs, HistoneAcetyltransferase, Histone Acetyltransferase, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, Ferroptosis, Turmeric yellow
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology
Purity
95.00% (May vary between batches)
Solubility
DMSO: 265.00 mg/mL (719.37 mM), Sonication is recommended. Ethanol: 1.80 mg/mL (4.89 mM), Sonication is recommended.
Smiles
COC1=CC (\C=C\C (=O) CC (=O) \C=C\C2=CC (OC) =C (O) C=C2) =CC=C1O
Molecular Formula
C21H20O6
Molecular Weight
368.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Curcumin

Curcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. It has a role as a geroprotector, a metabolite, a biological pigment, an antineoplastic agent, a flavouring agent, an antifungal agent, a lipoxygenase inhibitor, a dye, an iron chelator, an EC 1.1.1.21 (aldehyde reductase) inhibitor, a radical scavenger, a contraceptive drug, an EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor, a nutraceutical, an immunomodulator, a ligand, an EC 1.1.1.205 (IMP dehydrogenase) inhibitor, an EC 3.5.1.98 (histone deacetylase) inhibitor, a hepatoprotective agent, a neuroprotective agent, an EC 1.8.1.9 (thioredoxin reductase) inhibitor, an anti-inflammatory agent, an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, a food colouring and an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor. It is a polyphenol, an aromatic ether, an enone, a beta-diketone and a diarylheptanoid. It is functionally related to a trans-ferulic acid.

CAS Number458-37-7
PubChem CID969516
IUPAC Name(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Molecular FormulaC21H20O6
Molecular Weight368.4
XLogP3.2
Topological Polar Surface Area93.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count27
Formal Charge0
Complexity507
SMILES
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
InChI
InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChIKey
VFLDPWHFBUODDF-FCXRPNKRSA-N
Chemical Structure
2D Structure
2D structure of Curcumin
CAS: 458-37-7
CID: 969516
Formula: C21H20O6
MW: 368.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.4
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass368.12598835
Monoisotopic Mass368.12598835
Topological Polar Surface Area93.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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