Teniposide

CAT: 0013-GTR19175328-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0013-GTR19175328-03Size:1 ml x 10 mM (in DMSO)

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Description

Teniposide (VM-26) is a podophyllotoxin-derived chemotherapeutic agent that acts as a topoisomerase II inhibitor, stabilizing the enzyme-DNA complex to block DNA replication. It is widely used in cancer research, demonstrating activity in both in vitro cytotoxicity assays and in vivo models of leukemia and solid tumors.

CAS Number

29767-20-2

Product Name Alternative

NSC 122819, inhibit, NSC122819, NSC-122819, Inhibitor, Topoisomerase, Topo II, Teniposide, VM26, VM-26, VM 26

Field of Research

Molecular Biology, Pharmacology & Drug Discovery

Purity

96.98% (May vary between batches)

Solubility

DMSO:125 mg/mL (190.36 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.05 mM)

Smiles

O=C1[C@@]2 ([C@@H] (C=3C ([C@@H] (O[C@@H]4O[C@]5 ([C@] ([C@H] (O) [C@H]4O) (O[C@@H] (OC5) C6=CC=CS6) [H]) [H]) [C@]2 (CO1) [H]) =CC7=C (C3) OCO7) C8=CC (OC) =C (O) C (OC) =C8) [H]

Molecular Formula

C32H32O13S

Molecular Weight

656.65

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Teniposide

Teniposide can cause developmental toxicity according to state or federal government labeling requirements.

CAS Number	29767-20-2
PubChem CID	452548
IUPAC Name	(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Molecular Formula	C32H32O13S
Molecular Weight	656.7
XLogP	1.2
Topological Polar Surface Area	189
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	6
Heavy Atom Count	46
Formal Charge	0
Complexity	1090

SMILES

COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)CO[C@H](O7)C8=CC=CS8)O)O

InChI

InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1

InChIKey

NRUKOCRGYNPUPR-QBPJDGROSA-N

Chemical Structure

2D Structure

CAS: 29767-20-2

CID: 452548

Formula: C32H32O13S

MW: 656.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	656.7
XLogP3	1.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	6
Exact Mass	656.15636224
Monoisotopic Mass	656.15636224
Topological Polar Surface Area	189 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	1090
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
S1787-10mM/1mL	Teniposide

Teniposide

Chemical Information

Alternative Products

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