Products for Research Use Only
RegisterLogin

Ritonavir

CAT: 0013-GTR19175314-02Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19175314-02Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ritonavir (ABT-538) is a peptidomimetic inhibitor of HIV-1 and HIV-2 proteases. While its own antiviral activity is limited by serum protein binding, it is widely used in research, both in vitro and in vivo, as a potent cytochrome P450 inhibitor to pharmacokinetically boost other protease inhibitors.
CAS Number
155213-67-5
Product Name Alternative
ABT538, ABT-538, ABT 538, Abbott 84538, A 84538, A84538, A-84538, Apoptosis, HIVProtease, HIV Protease, HIV, Human immunodeficiency virus, Inhibitor, inhibit, Ritonavir, RTV, SARS-CoV, SARSCoV, SARS coronavirus
Field of Research
Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
>98%
Bioactivity
HIV1/2 protease inhibitor
Form
Powder
Solubility
Soluble in DMSO (12 mg/ml with warming) or in ethanol (5mg/ml)
Smiles
CC (C) [C@H] (NC (=O) N (C) CC1=CSC (=N1) C (C) C) C (=O) N[C@H] (C[C@H] (O) [C@H] (CC1=CC=CC=C1) NC (=O) OCC1=CN=CS1) CC1=CC=CC=C1
Molecular Formula
C37H48N6O5S2
Molecular Weight
720.9
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1,3-Thiazol-5-ylmethyl N-[ (2S,3S,5S) -3-hydroxy-5-[[ (2S) -3-methyl-2-[[methyl-2-[ (2-propan-2-yl-1,3-thiazol-4-yl) methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

Chemical Information

Ritonavir

Ritonavir is an L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. It has a role as a HIV protease inhibitor, a xenobiotic, an antiviral drug and an environmental contaminant. It is a carbamate ester, a carboxamide, a member of 1,3-thiazoles, a member of ureas and a L-valine derivative.

CAS Number155213-67-5
PubChem CID392622
IUPAC Name1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
Molecular FormulaC37H48N6O5S2
Molecular Weight720.9
XLogP6
Topological Polar Surface Area202
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count18
Heavy Atom Count50
Formal Charge0
Complexity1040
SMILES
CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
InChI
InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChIKey
NCDNCNXCDXHOMX-XGKFQTDJSA-N
Chemical Structure
2D Structure
2D structure of Ritonavir
CAS: 155213-67-5
CID: 392622
Formula: C37H48N6O5S2
MW: 720.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight720.9
XLogP36
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count18
Exact Mass720.31276100
Monoisotopic Mass720.31276100
Topological Polar Surface Area202 Ų
Heavy Atom Count50
Formal Charge0
Complexity1040
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A8203-5.1Ritonavir

Popular Products