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BMX-IN-1

CAT: 0013-GTR19175117-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175117-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMX-IN-1 is a potent and selective dual inhibitor of BMX and BTK kinases, with IC50 values of 8 nM and 10.4 nM, respectively. It demonstrates high selectivity, showing significantly reduced activity against Blk, JAK3, EGFR, Itk, and Tec. This inhibitor is a valuable chemical tool for studying TEC family kinase signaling in cancer and immunology research, both in vitro and in vivo.
CAS Number
1431525-23-3
Product Name Alternative
Inhibit, Inhibitor, BMX IN 1, BMX Kinase, BMX kinase inhibitor, Bruton tyrosine kinase, Btk, BTK, BMXIN1, BMX-IN-1, BMX, Bmx
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
≥98% (May vary between batches)
Solubility
DMSO:8 mg/mL (15.25 mM) ; DMF:9 mg/mL (17.16 mM)
Smiles
Cc1ccc (cc1NC (=O) C=C) -n1c2c (ccc1=O) cnc1ccc (cc21) -c1ccc (NS (C) (=O) =O) cc1
Molecular Formula
C29H24N4O4S
Molecular Weight
524.59
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Bmx-IN-1

a BMX tyrosine kinase inhibitor; structure in first source

CAS Number1431525-23-3
PubChem CID71576693
IUPAC NameN-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamide
Molecular FormulaC29H24N4O4S
Molecular Weight524.6
XLogP4.1
Topological Polar Surface Area117
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity1030
SMILES
CC1=C(C=C(C=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CC=C(C=C5)NS(=O)(=O)C)NC(=O)C=C
InChI
InChI=1S/C29H24N4O4S/c1-4-27(34)31-26-16-23(12-5-18(26)2)33-28(35)14-9-21-17-30-25-13-8-20(15-24(25)29(21)33)19-6-10-22(11-7-19)32-38(3,36)37/h4-17,32H,1H2,2-3H3,(H,31,34)
InChIKey
SFMJNHNUOVADRW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bmx-IN-1
CAS: 1431525-23-3
CID: 71576693
Formula: C29H24N4O4S
MW: 524.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight524.6
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass524.15182643
Monoisotopic Mass524.15182643
Topological Polar Surface Area117 Ų
Heavy Atom Count38
Formal Charge0
Complexity1030
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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A3260-50BMX-IN-1
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A15027-5BMX-IN-1 5mg
A15027-50BMX-IN-1 50mg
A15027-25BMX-IN-1 25mg
A15027-10BMX-IN-1 10mg
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