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BRD6989

CAT: 0013-GTR19175095-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175095-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRD6989 is a synthetic analog of cortistatin A that acts as a selective CDK8/19 kinase inhibitor, demonstrating an IC50 of approximately 200 nM. This compound is a valuable research tool for studying CDK8-mediated transcriptional regulation and has been utilized in both in vitro and in vivo models to investigate immunomodulation and oncology pathways.
CAS Number
642008-81-9
Product Name Alternative
Cortistatin-A, CDK19/CycC, CDK19, CDK8/CycC, CDK8, BRD6989, BRD-6989, BRD 6989, CDK, Cyclin dependent kinase, BMDCs, Inhibitor, inhibit, ILReceptor, inflammatory, Interleukin, Interleukin Related, IL Receptor, IL-10, recombinant CDK19, recombinant CDK8
Field of Research
Cell Biology, Immunology & Inflammation
Purity
98.82% (May vary between batches)
Solubility
DMSO:11 mg/mL (41.61 mM) ;10% DMSO+90% Corn Oil:1 mg/mL (3.78 mM)
Smiles
CC1CCc2nc (N) c (C#N) c (-c3cccnc3) c2C1
Molecular Formula
C16H16N4
Molecular Weight
264.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-Amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile is a member of bipyridines.

CAS Number642008-81-9
PubChem CID3835861
IUPAC Name2-amino-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Molecular FormulaC16H16N4
Molecular Weight264.32
XLogP2.8
Topological Polar Surface Area75.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity387
SMILES
CC1CCC2=C(C1)C(=C(C(=N2)N)C#N)C3=CN=CC=C3
InChI
InChI=1S/C16H16N4/c1-10-4-5-14-12(7-10)15(11-3-2-6-19-9-11)13(8-17)16(18)20-14/h2-3,6,9-10H,4-5,7H2,1H3,(H2,18,20)
InChIKey
QSYBDNXNOJIKML-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
CAS: 642008-81-9
CID: 3835861
Formula: C16H16N4
MW: 264.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight264.32
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass264.137496527
Monoisotopic Mass264.137496527
Topological Polar Surface Area75.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity387
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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