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Pilaralisib

CAT: 0013-GTR19174988-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19174988-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pilaralisib (XL-147) is a selective, orally bioavailable phosphoinositide-3 kinase (PI3K) inhibitor. It has been widely employed in preclinical and clinical research, including in vitro cell-based assays and in vivo xenograft models, to investigate its therapeutic potential in cancers such as breast cancer, lymphoma, and glioblastoma.
CAS Number
934526-89-3
Product Name Alternative
Inhibitor, inhibit, SAR 245408, SAR245408, SAR-245408, PI3K, Phosphoinositide 3-kinase, XL 147, XL-147, XL147, PI3Kδ, PI3Kβ, PI3Kγ, PI3Kα, Pilaralisib
Field of Research
Signal Transduction
Purity
98.24% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:93 mg/mL (171.9 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.1 mM)
Smiles
COc1ccc (Cl) c (Nc2nc3ccccc3nc2NS (=O) (=O) c2cccc (NC (=O) C (C) (C) N) c2) c1
Molecular Formula
C25H25ClN6O4S
Molecular Weight
541.02
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pilaralisib

Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Glioblastoma, and Breast Cancer, among others.

CAS Number934526-89-3
PubChem CID56599306
IUPAC Name2-amino-N-[3-[[3-(2-chloro-5-methoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide
Molecular FormulaC25H25ClN6O4S
Molecular Weight541.0
XLogP3.4
Topological Polar Surface Area157
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Heavy Atom Count37
Formal Charge0
Complexity887
SMILES
CC(C)(C(=O)NC1=CC(=CC=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=C(C=CC(=C4)OC)Cl)N
InChI
InChI=1S/C25H25ClN6O4S/c1-25(2,27)24(33)28-15-7-6-8-17(13-15)37(34,35)32-23-22(29-19-9-4-5-10-20(19)30-23)31-21-14-16(36-3)11-12-18(21)26/h4-14H,27H2,1-3H3,(H,28,33)(H,29,31)(H,30,32)
InChIKey
QINPEPAQOBZPOF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pilaralisib
CAS: 934526-89-3
CID: 56599306
Formula: C25H25ClN6O4S
MW: 541.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight541.0
XLogP33.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass540.1346522
Monoisotopic Mass540.1346522
Topological Polar Surface Area157 Ų
Heavy Atom Count37
Formal Charge0
Complexity887
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
462620-01Pilaralisib
C12840-5mgPilaralisib (XL147)
T2377-01Pilaralisib analogue
HY-16526R-01Pilaralisib (Standard)
SF2775-25mgPilaralisib (PI3K inhibitor)
MBS130750-01Pilaralisib (XL-147)
MBS386102-01XL-147 (Pilaralisib)
A15283-100XL-147 (Pilaralisib) 100mg

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