L-822179

CAT: 0013-GTR19174874-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19174874-01Size:1 mg

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Description

L-822179 (α5IA) is a selective inverse agonist with high intrinsic activity at the α5-GABAA receptor subtype. It is a valuable research tool for investigating the role of α5-containing receptors in cognitive processes and memory, both in vitro and in animal models of CNS disorders.

CAS Number

215874-86-5

Product Name Alternative

L 822,179, L 822179, GABA Receptor, GABAReceptor, GABAA α5, L822,179, L-822,179, L822179, L-822179

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

98.34% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:< 1 mg/mL (insoluble or slightly soluble)

Smiles

Cc1cc (no1) -c1nnc2c3ccccc3c (OCc3cn (C) nn3) nn12

Molecular Formula

C17H14N8O2

Molecular Weight

362.35

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

3-(5-Methylisoxazol-3-yl)-6-((1-methyl-1,2,3-triazol-4-yl)methyloxy)-1,2,4-triazolo(3,4-a)phthalazine

a GABA A receptor inverse agonist

CAS Number	215874-86-5
PubChem CID	6918451
IUPAC Name	5-methyl-3-[6-[(1-methyltriazol-4-yl)methoxy]-[1,2,4]triazolo[3,4-a]phthalazin-3-yl]-1,2-oxazole
Molecular Formula	C17H14N8O2
Molecular Weight	362.3
XLogP	1.1
Topological Polar Surface Area	109
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	27
Formal Charge	0
Complexity	527

SMILES

CC1=CC(=NO1)C2=NN=C3N2N=C(C4=CC=CC=C43)OCC5=CN(N=N5)C

InChI

InChI=1S/C17H14N8O2/c1-10-7-14(22-27-10)16-20-19-15-12-5-3-4-6-13(12)17(21-25(15)16)26-9-11-8-24(2)23-18-11/h3-8H,9H2,1-2H3

InChIKey

NZMJFRXKGUCYNP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 215874-86-5

CID: 6918451

Formula: C17H14N8O2

MW: 362.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	362.3
XLogP3	1.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	362.12397172
Monoisotopic Mass	362.12397172
Topological Polar Surface Area	109 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	527
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
M27776-01	L-822179
CCP1053-01	A-L-A-L
453309-01	L-Glycyl-L-lysyl-L-leucyl-L-isoleucyl-L-tyrosyl-L-seryl-L-alanyl-L-seryl-L-phenylalanyl-L-leucyl-L-tyrosyl-L-seryl-L-glycyl-L-valyl-L-prolyl-L-seryl-L-arganine
453434-01	L-Seryl-L-threonyl-L-glycyl-L-isoleucyl-L-seryl-L-valyl-L-prolyl-L-glycyl-L-prolyl-L-methionyl-L-glycyl-L-prolyl-L-seryl-L-glycyl-L-prolyl-L-Arginine
JH918176	L-Arginine, L-valyl-L-seryl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginylglycylglycyl-L-arginyl-L-arginyl-L-arginyl-
453216-01	L-Arginyl-L-valyl-L-α-aspartyl-L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine
453308-01	L-Glycyl-L-arginyl-L-phenylalanyl-L-isoleucyl-L-threonyl-L-seryl-L-alanyl-L-aspartyl-L-threonyl-L-lysine
918629-48-8	L-Alanyl-L-Cysteinyl-L-Seryl-L-Seryl-L-Seryl-L-Prolyl-L-Seryl-L-Lysyl-L-Histidyl-L-Cysteinylglycine
453464-01	L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine
OR1066054-01	L-Tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl-L-tyrosine

L-822179

Chemical Information

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