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GSK3987

CAT: 0013-GTR19174650-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174650-05Size:25 mg
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Description
GSK3987 is a synthetic ligand for Liver X Receptors (LXRα and LXRβ), demonstrating potent agonist activity by recruiting the steroid receptor coactivator-1 with EC50 values of 40 nM. This small molecule is a valuable research tool for studying LXR-mediated pathways in lipid metabolism, inflammation, and atherosclerosis in both cellular and animal models.
CAS Number
264206-85-1
Product Name Alternative
LXR, LXRβ, LXRα, LiverXReceptor, Liver X receptor, Liver X Receptor, inhibit, macrophages, GSK3987, GSK-3987, GSK 3987, Inhibitor, HepG2 cells, ABCA1, cellular cholesterol, SREBP-1c, triglyceride accumulation
Field of Research
Metabolism Research
Purity
99.48% (May vary between batches)
Solubility
DMSO:50 mg/mL (130.06 mM)
Smiles
COc1ccc (NC2=C (C (=O) N (Cc3ccccc3) C2=O) c2ccccc2) cc1
Molecular Formula
C24H20N2O3
Molecular Weight
384.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-Benzyl-3-(4-methoxyphenylamino)-4-phenylpyrrole-2,5-dione
CAS Number264206-85-1
PubChem CID5288679
IUPAC Name1-benzyl-3-(4-methoxyanilino)-4-phenylpyrrole-2,5-dione
Molecular FormulaC24H20N2O3
Molecular Weight384.4
XLogP4.3
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity624
SMILES
COC1=CC=C(C=C1)NC2=C(C(=O)N(C2=O)CC3=CC=CC=C3)C4=CC=CC=C4
InChI
InChI=1S/C24H20N2O3/c1-29-20-14-12-19(13-15-20)25-22-21(18-10-6-3-7-11-18)23(27)26(24(22)28)16-17-8-4-2-5-9-17/h2-15,25H,16H2,1H3
InChIKey
HLZMYWLMBBLASX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Benzyl-3-(4-methoxyphenylamino)-4-phenylpyrrole-2,5-dione
CAS: 264206-85-1
CID: 5288679
Formula: C24H20N2O3
MW: 384.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.4
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass384.14739250
Monoisotopic Mass384.14739250
Topological Polar Surface Area58.6 Ų
Heavy Atom Count29
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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