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Lenalidomide

CAT: 0013-GTR19174558-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174558-01Size:100 mg
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Description
Lenalidomide is an orally active immunomodulatory agent that functions as a cereblon (CRBN) ligand. It induces the CRBN-CRL4 E3 ubiquitin ligase to selectively target and degrade the transcription factors IKZF1 and IKZF3. This mechanism underpins its research applications in hematology, immunology, and as a foundational component in PROTAC development for targeted protein degradation studies.
CAS Number
191732-72-6
Product Name Alternative
CC-5013
Field of Research
Cardiovascular Research, Immunology & Inflammation
Purity
>98%
Bioactivity
TNFa inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml) .
Smiles
NC1=C2CN (C3CCC (=O) NC3=O) C (=O) C2=CC=C1
Molecular Formula
C13H13N3O3
Molecular Weight
259.26
Storage Conditions
RT
Notes
For research use only.
Other Product Names
(R, S) -3- (4-Amino-1-oxo-3H-isoindol-2-yl) piperidine-2,6-dione

Chemical Information

Lenalidomide

Lenalidomide is a dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an immunomodulator. It is a member of isoindoles, an aromatic amine, a dicarboximide and a member of piperidones.

CAS Number191732-72-6
PubChem CID216326
IUPAC Name3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Molecular FormulaC13H13N3O3
Molecular Weight259.26
XLogP-0.5
Topological Polar Surface Area92.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity437
SMILES
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
InChI
InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChIKey
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lenalidomide
CAS: 191732-72-6
CID: 216326
Formula: C13H13N3O3
MW: 259.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight259.26
XLogP3-0.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass259.09569129
Monoisotopic Mass259.09569129
Topological Polar Surface Area92.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity437
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FL24864-01Lenalidomide

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