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GSK2256294A

CAT: 0013-GTR19174480-05Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174480-05Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK2256294A is a highly potent and selective soluble epoxide hydrolase (sEH) inhibitor, demonstrating sub-nanomolar IC50 values against human, rat, and mouse enzymes. This compound is a valuable research tool for investigating the role of sEH in cardiovascular, pulmonary, and metabolic diseases in both in vitro and in vivo models.
CAS Number
1142090-23-0
Product Name Alternative
Inflammation, inhibit, oral, Inhibitor, Epoxide Hydrolase, EpoxideHydrolase, GSK 2256294, GSK2256294, GSK-2256294, GSK2256294A, GSK-2256294A, cardiovascular, COPD, cigarette smoke-exposure model, sEH
Field of Research
Metabolism Research
Purity
98.65% (May vary between batches)
Solubility
DMSO:4.48 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.23 mM)
Smiles
CNc1nc (C) nc (N[C@H]2CCC[C@H] (C2) C (=O) NCc2ccc (cc2C (F) (F) F) C#N) n1
Molecular Formula
C21H24F3N7O
Molecular Weight
447.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gsk-2256294
CAS Number1142090-23-0
PubChem CID59448236
IUPAC Namecis-(1R,3S)-N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]cyclohexane-1-carboxamide
Molecular FormulaC21H24F3N7O
Molecular Weight447.5
XLogP3.7
Topological Polar Surface Area116
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity682
SMILES
CC1=NC(=NC(=N1)N[C@H]2CCC[C@H](C2)C(=O)NCC3=C(C=C(C=C3)C#N)C(F)(F)F)NC
InChI
InChI=1S/C21H24F3N7O/c1-12-28-19(26-2)31-20(29-12)30-16-5-3-4-14(9-16)18(32)27-11-15-7-6-13(10-25)8-17(15)21(22,23)24/h6-8,14,16H,3-5,9,11H2,1-2H3,(H,27,32)(H2,26,28,29,30,31)/t14-,16+/m1/s1
InChIKey
LQHDJQIMETZMPH-ZBFHGGJFSA-N
Chemical Structure
2D Structure
2D structure of Gsk-2256294
CAS: 1142090-23-0
CID: 59448236
Formula: C21H24F3N7O
MW: 447.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight447.5
XLogP33.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass447.19944290
Monoisotopic Mass447.19944290
Topological Polar Surface Area116 Ų
Heavy Atom Count32
Formal Charge0
Complexity682
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA7684-10GSK2256294A
A20696-50GSK2256294A 50mg
A20696-100GSK2256294A 100mg
A20696-2GSK2256294A 2mg
A20696-25GSK2256294A 25mg
A20696-10GSK2256294A 10mg
A20696-1GSK2256294A 1mg
A20696-5GSK2256294A 5mg

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