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GW7647

CAT: 0013-GTR19174467-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174467-01Size:1 mg
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Description
GW 7647 is a potent and selective PPARα agonist, demonstrating EC50 values of 6 nM, 1100 nM, and 6200 nM for human PPARα, PPARγ, and PPARδ, respectively. Its ability to reduce nitric oxide in macrophages underpins its utility in studying lipid metabolism and inflammation in both cellular and animal models.
CAS Number
265129-71-3
Product Name Alternative
GW 7647, GW7647, GW-7647, Inhibitor, inhibit, PPARδ, PPARγ, PPARα, PPAR, Peroxisome proliferator-activated receptors
Field of Research
Metabolism Research, Molecular Biology
Purity
99.30% (May vary between batches)
Solubility
DMSO:81.67 mg/mL (162.45 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.98 mM)
Smiles
CC (C) (Sc1ccc (CCN (CCCCC2CCCCC2) C (=O) NC2CCCCC2) cc1) C (O) =O
Molecular Formula
C29H46N2O3S
Molecular Weight
502.75
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

GW-7647

GW 7647 is a monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group. It has a role as a PPARalpha agonist. It is a monocarboxylic acid, an aryl sulfide and a member of ureas.

CAS Number265129-71-3
PubChem CID3392731
IUPAC Name2-[4-[2-[4-cyclohexylbutyl(cyclohexylcarbamoyl)amino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid
Molecular FormulaC29H46N2O3S
Molecular Weight502.8
XLogP8
Topological Polar Surface Area94.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count12
Heavy Atom Count35
Formal Charge0
Complexity636
SMILES
CC(C)(C(=O)O)SC1=CC=C(C=C1)CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3
InChI
InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
InChIKey
PKNYXWMTHFMHKD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of GW-7647
CAS: 265129-71-3
CID: 3392731
Formula: C29H46N2O3S
MW: 502.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight502.8
XLogP38
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count12
Exact Mass502.32291451
Monoisotopic Mass502.32291451
Topological Polar Surface Area94.9 Ų
Heavy Atom Count35
Formal Charge0
Complexity636
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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