Rigosertib

CAT: 0013-GTR19174219-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19174219-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Rigosertib (ON-01910) is a potent, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor that induces apoptosis via PI3K/Akt pathway inhibition, promotes histone H2AX phosphorylation, and causes G2/M cell cycle arrest. It has demonstrated anti-tumor activity in both in vitro and in vivo cancer research models, including studies in myelodysplastic syndromes.

CAS Number

592542-59-1

Product Name Alternative

Cdk1, Apoptosis, BCR-ABL, BcrAbl, Inhibitor, Flt1, Fyn, ON01910, ON-01910, ON 01910, PLK1, PLK, PLK2, inhibit, Src, Rigosertib, Polo-like Kinase (PLK), PDGFR, Phosphoinositide 3-kinase, PI3K

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Purity

97.33% (May vary between batches)

Solubility

DMSO:75 mg/mL (166.12 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.43 mM)

Smiles

C (=C/S (CC1=CC (NCC (O) =O) =C (OC) C=C1) (=O) =O) \C2=C (OC) C=C (OC) C=C2OC

Molecular Formula

C21H25NO8S

Molecular Weight

451.49

Storage Conditions

-20°C

Notes

For research use only.

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Catalog	Name
MBS3600864-01	Rigosertib
SYA54259-01	Rigosertib-d6
202080	Rigosertib sodium
HY-12037-01	Rigosertib (sodium)
MBS130460-01	Rigosertib (ON-01910)
A21868-2	Rigosertib 2mg
MBS385857-01	ON-01910 (rigosertib)

Rigosertib

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