Protocadherin FAT2 (FAT Atypical Cadherin 2)

• Gene Name:

  [FAT2]

• NCBI Gene ID:

  2196

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 480kDa, which is identified as FAT2. The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain, two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.

• Other Gene Names:

  [FAT2; FAT2; CDHF8; CDHR9; HFAT2; MEGF1; SCA45; CDHF8; KIAA0811; MEGF1; hFat2; Multiple EGF-like domains protein 1]

• Short Name:

  [Protocadherin FAT2]

• Other Product Names:

  [protocadherin Fat 2; Protocadherin Fat 2; protocadherin Fat 2; FAT atypical cadherin 2; Cadherin family member 8; Multiple epidermal growth factor-like domains protein 1; Multiple EGF-like domains protein 1]

• NCBI GI Number:

  13787217

• NCBI Accession Number:

  NP_001438.1

• NCBI GB Accession Number:

  NM_001447.2

• Uniprot Accession Number:

  Q9NYQ8