Catenin, beta (p120)

• Gene Name:

  [CTNNB1]

• NCBI Gene ID:

  1499

• Reactivity:

  Human, Cow, Dog, Chicken. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  This MAb recognizes a protein of 92kDa, which is identified as beta-catenin. It shows no cross-reaction with gamma-catenin (also known as plakoglobin). The catenins, alpha, beta and gamma bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin was initially described as an E-cadherin-associated protein, and has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin has also been found in complexes with the tumor suppressor protein APC.

• Other Gene Names:

  [CTNNB1; CTNNB1; EVR7; CTNNB; MRD19; armadillo; CTNNB]

• Short Name:

  [Catenin, beta]

• Other Product Names:

  [catenin beta-1 isoform 1; Catenin beta-1; catenin beta-1; catenin beta 1; Beta-catenin]

• NCBI GI Number:

  148233338

• NCBI Accession Number:

  NP_001091679.1

• NCBI GB Accession Number:

  NM_001098209.1

• Uniprot Accession Number:

  P35222