Clathrin, Light Chain

• Gene Name:

  [CLTA]

• NCBI Gene ID:

  1211

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes proteins of 31-44kDa, which are identified as Clathrin Light Chains (both A & B). Clathrin is composed of three heavy chains and three light chains, which associate non-covalently to form a triskelion structure. Clathrin light chain regulates the self-assembly of triskelions onto intracellular membranes. Clathrin light chain subunits (LCA and LCB) contribute to regulation of coated vesicle formation to sort proteins during receptor-mediated endocytosis and organelle biogenesis. LCA and LCB are encoded by two discrete genes. They share only 60% homology, and have certain features in common. Both LCA and LCB undergo alternative mRNA splicing, which results in the generation of tissue-specific isoforms.

• Other Gene Names:

  [CLTA; CLTA; LCA; Lca]

• Short Name:

  [Clathrin, Light Chain]

• Other Product Names:

  [clathrin light chain A isoform c; Clathrin light chain A; clathrin light chain A; clathrin light chain A]

• NCBI GI Number:

  115527060

• NCBI Accession Number:

  NP_001070145.1

• NCBI GB Accession Number:

  NM_001076677.2

• Uniprot Accession Number:

  P09496