CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)

CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)

• Gene Name: [CFTR]
• NCBI Gene ID: 1080
• Reactivity: Human. Others not known.
• Storage Conditions: Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3', 5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
• Other Gene Names: [CFTR; CFTR; CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1; ABCC7; CFTR]
• Short Name: [CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)]
• Other Product Names: [cystic fibrosis transmembrane conductance regulator; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49]
• NCBI GI Number: 90421313
• NCBI Accession Number: NP_000483.3
• NCBI GB Accession Number: NM_000492.3
• Uniprot Accession Number: P13569