Cyclin B1 (G2- & M-phase Cyclin) Mouse Monoclonal Antibody

Cyclin B1 (G2- & M-phase Cyclin) Mouse Monoclonal Antibody

• CAS Number: 9007-83-4
• Gene Name: [CCNB1]
• NCBI Gene ID: 891
• Reactivity: Human, Mouse
• Storage Conditions: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
• Other Gene Names: [CCNB1; CCNB1; CCNB; CCNB]
• Short Name: [Cyclin B1]
• Other Product Names: [G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; cyclin B1]
• NCBI GI Number: 14327896
• NCBI Accession Number: NP_114172.1
• NCBI GB Accession Number: NM_031966.3
• Uniprot Accession Number: P14635