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Solithromycin

CAT: 0013-GTR19173904-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173904-06Size:50 mg
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Description
Solithromycin is a novel, orally bioavailable macrolide antibiotic that potently inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It demonstrates in vitro efficacy against key respiratory pathogens like Streptococcus pneumoniae and Haemophilus influenzae and has been investigated in clinical trials for community-acquired bacterial pneumonia.
CAS Number
760981-83-7
Product Name Alternative
OP1068, OP-1068, OP 1068, Inhibitor, inhibit, Antibiotic, Bacterial, CEM101, CEM-101, CEM 101, Solithromycin
Field of Research
Infectious Disease & Virology
Purity
98.34% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.37 mM) ; DMSO:50 mg/mL (59.17 mM)
Smiles
CC[C@H]1OC (=O) [C@@] (C) (F) C (=O) [C@H] (C) [C@@H] (O[C@@H]2O[C@H] (C) C[C@@H] ([C@H]2O) N (C) C) [C@@] (C) (C[C@@H] (C) C (=O) [C@H] (C) [C@H]2N (CCCCn3cc (nn3) -c3cccc (N) c3) C (=O) O[C@]12C) OC
Molecular Formula
C43H65FN6O10
Molecular Weight
845.01
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Solithromycin

Solithromycin is an aminoglycoside.

CAS Number760981-83-7
PubChem CID25242512
IUPAC Name(1S,2R,5S,7R,8R,9R,11R,13R,14R)-15-[4-[4-(3-aminophenyl)triazol-1-yl]butyl]-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-5-fluoro-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
Molecular FormulaC43H65FN6O10
Molecular Weight845.0
XLogP4.3
Topological Polar Surface Area198
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count15
Rotatable Bond Count11
Heavy Atom Count60
Formal Charge0
Complexity1530
SMILES
CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@](C(=O)O1)(C)F)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C
InChI
InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
InChIKey
IXXFZUPTQVDPPK-ZAWHAJPISA-N
Chemical Structure
2D Structure
2D structure of Solithromycin
CAS: 760981-83-7
CID: 25242512
Formula: C43H65FN6O10
MW: 845.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight845.0
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count15
Rotatable Bond Count11
Exact Mass844.47462045
Monoisotopic Mass844.47462045
Topological Polar Surface Area198 Ų
Heavy Atom Count60
Formal Charge0
Complexity1530
Isotope Atom Count0
Defined Atom Stereocenter Count13
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B5918-5Solithromycin
SC3278-10mMSolithromycin (Antibacterial)

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