SUMO-2 Mouse Monoclonal Antibody

• Gene Name:

  [SUMO2]

• NCBI Gene ID:

  6612

• Reactivity:

  Human, Rat.
  Predicted to show a broad species reactivity

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer s disease.

• Other Gene Names:

  [SUMO3; SUMO3; SMT3A; Smt3B; SMT3H1; SUMO-3; Smt3A]

• Short Name:

  [SUMO-2]

• Other Product Names:

  [small ubiquitin-related modifier 3 isoform 2; Small ubiquitin-related modifier 3; small ubiquitin-related modifier 3; small ubiquitin-like modifier 3; SMT3 homolog 1]

• NCBI GI Number:

  556695502

• NCBI Accession Number:

  NP_001273345.1

• NCBI GB Accession Number:

  NM_001286416.1

• Uniprot Accession Number:

  P55854

• CAS Number:

  9007-83-4