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AZ-5104

CAT: 0013-GTR19173829-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173829-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ5104 is a selective and potent small molecule inhibitor of the epidermal growth factor receptor (EGFR) . It is widely used in biochemical and cellular assays to study EGFR-driven signaling pathways and has demonstrated research utility in both in vitro and in vivo models of oncology.
CAS Number
1421373-98-9
Product Name Alternative
Inhibit, Inhibitor, HER1, HER2/ErbB2, EGFR, EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (wildtype), Epidermal growth factor receptor, ErbB-1, AZ5104, AZ-5104, AZ 5104
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.40% (May vary between batches)
Solubility
Ethanol:16 mg/mL (32.95 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.8 mM) ; DMSO:90 mg/mL (185.35 mM)
Smiles
COc1cc (N (C) CCN (C) C) c (NC (=O) C=C) cc1Nc1nccc (n1) -c1c[nH]c2ccccc12
Molecular Formula
C27H31N7O2
Molecular Weight
485.58
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AZ-5104

an EGFR inhibitor

CAS Number1421373-98-9
PubChem CID71496460
IUPAC NameN-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Molecular FormulaC27H31N7O2
Molecular Weight485.6
XLogP3.8
Topological Polar Surface Area98.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count36
Formal Charge0
Complexity722
SMILES
CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
InChI
InChI=1S/C27H31N7O2/c1-6-26(35)30-22-15-23(25(36-5)16-24(22)34(4)14-13-33(2)3)32-27-28-12-11-21(31-27)19-17-29-20-10-8-7-9-18(19)20/h6-12,15-17,29H,1,13-14H2,2-5H3,(H,30,35)(H,28,31,32)
InChIKey
IQNVEOMHJHBNHC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AZ-5104
CAS: 1421373-98-9
CID: 71496460
Formula: C27H31N7O2
MW: 485.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight485.6
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass485.25392326
Monoisotopic Mass485.25392326
Topological Polar Surface Area98.4 Ų
Heavy Atom Count36
Formal Charge0
Complexity722
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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