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MPEP HCl

CAT: 0013-GTR19173820-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173820-02Size:25 mg
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Description
MPEP hydrochloride is a potent and selective non-competitive antagonist of the metabotropic glutamate receptor 5 (mGlu5), exhibiting an IC50 of 36 nM. It is a valuable research tool for investigating mGlu5 function in neurological and psychiatric disorders, widely used in both in vitro binding assays and in vivo behavioral studies.
CAS Number
219911-35-0
Product Name Alternative
Inhibit, Inhibitor, MPEP, MPEP hydrochloride, MPEP Hydrochloride, mGluR, Metabotropic glutamate receptors
Field of Research
Neuroscience
Purity
>98%
Bioactivity
Metabotropic glutamate receptor antagonist
Form
Powder
Solubility
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml) .
Smiles
Cl.Cc1cccc (n1) C#Cc1ccccc1
Molecular Formula
C14H11N·HCl
Molecular Weight
229.71
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Methyl-6- (2-phenylethynyl) pyridine hydrochloride

Chemical Information

2-Methyl-6-(phenylethynyl)pyridine hydrochloride

2-methyl-6-(phenylethynyl)pyridine hydrochloride is a hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as an anxiolytic drug and a metabotropic glutamate receptor antagonist. It contains a 2-methyl-6-(phenylethynyl)pyridinium(1+).

CAS Number219911-35-0
PubChem CID9794588
IUPAC Name2-methyl-6-(2-phenylethynyl)pyridine;hydrochloride
Molecular FormulaC14H12ClN
Molecular Weight229.70
Topological Polar Surface Area12.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count16
Formal Charge0
Complexity251
SMILES
CC1=NC(=CC=C1)C#CC2=CC=CC=C2.Cl
InChI
InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChIKey
PKDHDJBNEKXCBI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Methyl-6-(phenylethynyl)pyridine hydrochloride
CAS: 219911-35-0
CID: 9794588
Formula: C14H12ClN
MW: 229.70
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight229.70
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass229.0658271
Monoisotopic Mass229.0658271
Topological Polar Surface Area12.9 Ų
Heavy Atom Count16
Formal Charge0
Complexity251
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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