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BI-69A11

CAT: 0013-GTR19173795-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173795-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI-69A11 is a dual inhibitor of the AKT and NF-κB signaling pathways. This small molecule compound has been shown in research to sensitize colon cancer cells to growth inhibition by mda-7/IL-24 in vitro, making it a tool for studying oncogenic pathways and therapeutic resistance.
CAS Number
1233322-09-2
Product Name Alternative
NF-κB, NFκB, NFkB, NF-kB, (E) -3- (1H-Benzo[d]imidazol-2-yl) -1- (6-chloro-2-hydroxy-4-phenylquinolin-3-yl) prop-2-en-1-one, Akt, BI69A11, BI-69A11, BI-69A-11, BI 69A11
Field of Research
Signal Transduction
Purity
96.97% (May vary between batches)
Solubility
DMSO:55 mg/mL (129.15 mM)
Smiles
Clc1ccc2[nH]c (=O) c (C (=O) \C=C\c3nc4ccccc4[nH]3) c (-c3ccccc3) c2c1
Molecular Formula
C25H16ClN3O2
Molecular Weight
425.87
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(E)-3-(1H-benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one

(E)-3-(1H-benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one has been reported in Elephantopus mollis, Glochidion eriocarpum, and other organisms with data available.

CAS Number1233322-09-2
PubChem CID5343381
IUPAC Name3-[(E)-3-(1H-benzimidazol-2-yl)prop-2-enoyl]-6-chloro-4-phenyl-1H-quinolin-2-one
Molecular FormulaC25H16ClN3O2
Molecular Weight425.9
XLogP4.7
Topological Polar Surface Area74.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity773
SMILES
C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)/C=C/C4=NC5=CC=CC=C5N4
InChI
InChI=1S/C25H16ClN3O2/c26-16-10-11-18-17(14-16)23(15-6-2-1-3-7-15)24(25(31)29-18)21(30)12-13-22-27-19-8-4-5-9-20(19)28-22/h1-14H,(H,27,28)(H,29,31)/b13-12+
InChIKey
SBOKKVUBLNZTCT-OUKQBFOZSA-N
Chemical Structure
2D Structure
2D structure of (E)-3-(1H-benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one
CAS: 1233322-09-2
CID: 5343381
Formula: C25H16ClN3O2
MW: 425.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight425.9
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass425.0931045
Monoisotopic Mass425.0931045
Topological Polar Surface Area74.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity773
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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