CD8a

• Gene Name :

  [CD8A]

• NCBI Gene ID :

  925

• Reactivity :

  Human.

• Storage Conditions :

  Store at 2 to 8 °C. Antibody is stable for 24 months.

• Specificity :

  CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

• Other Gene Names :

  [CD8A; CD8A; CD8; MAL; p32; Leu2; MAL]

• Short Name :

  [CD8a]

• Other Product Names :

  [T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a]

• NCBI GI Number :

  225007536

• NCBI Accession Number :

  NP_001139345.1

• NCBI GB Accession Number :

  NM_001145873.1

• Uniprot Accession Number :

  P01732