Ivacaftor

CAT: 0013-GTR19173715-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19173715-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Ivacaftor (VX-770) is a CFTR potentiator effective on G551D and F508del mutants, with EC50 values of 100 nM and 25 nM, respectively, in Fisher rat thyroid cell assays. It is a key research tool for studying CFTR channel function and rescue in cellular models of cystic fibrosis, supporting both in vitro and preclinical in vivo research.

CAS Number

873054-44-5

Product Name Alternative

Inhibit, Ivacaftor, Ivacaftor (VX-770), G551D-CFTR, F508del-CFTR, Inhibitor, Autophagy, Cystic fibrosis transmembrane conductance regulator, CFTR, VX770, VX-770, VX 770

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Purity

98.00% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:252 mg/mL (642.05 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.74 mM)

Smiles

C (C) (C) (C) C1=C (NC (=O) C=2C (=O) C=3C (NC2) =CC=CC3) C=C (O) C (C (C) (C) C) =C1

Molecular Formula

C24H28N2O3

Molecular Weight

392.49

Storage Conditions

-20°C

Notes

For research use only.

Alternative Products

Catalog	Name
HY-13017-01	Ivacaftor
A3510-100	Ivacaftor benzenesulfonate
JVB82207-01	Ivacaftor hydrate
sc-489096	Ivacaftor-d19
AR-I04257-01	Ivacaftor-d18

Ivacaftor

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