CD33

• Gene Name:

  [CD33]

• NCBI Gene ID:

  945

• Reactivity:

  Human.

• Storage Conditions:

  Store at 2 to 8 °C. Antibody is stable for 24 months.

• Specificity:

  Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

• Other Gene Names:

  [CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3]

• Short Name:

  [CD33]

• Other Product Names:

  [myeloid cell surface antigen CD33 isoform 2; Myeloid cell surface antigen CD33; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; CD33 molecule; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33]

• NCBI GI Number:

  130980072

• NCBI Accession Number:

  NP_001076087.1

• NCBI GB Accession Number:

  NM_001082618.1

• Uniprot Accession Number:

  P20138