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Cyclin B1

CAT: 0544-MBS438370-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
CAT#:0544-MBS438370-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[CCNB1]
NCBI Gene ID
891
Reactivity
Human, Mouse, Hamster.
Storage Conditions
Store at 2 to 8 °C. Antibody is stable for 24 months.
Specificity
It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
Other Gene Names
[CCNB1; CCNB1; CCNB; CCNB]
Short Name
[Cyclin B1]
Other Product Names
[G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin B1; cyclin B1]
NCBI GI Number
14327896
NCBI Accession Number
NP_114172.1
NCBI GB Accession Number
NM_031966.3
Uniprot Accession Number
P14635

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Alternative Products

CatalogName
221964-01Cyclin A (Cyclin-A1, CCNA1, Cyclin A1, CyclinA1, Cyclin-A2, Cyclin-A, Cyclin A, CyclinA, CCNA2, CCN1, CCNA) discontinued
254004Cyclin A (CCN1, CCNA, Ccna2, CCNA2_HUMAN, Cyclin A2, Cyclin-A, Cyclin-A2)
E8ET1612-8Cyclin A1+ Cyclin A2
301337Cyclin E1 (Cyclin-E1)
C8452-08Cyclin A
C8452-06CCyclin A2 (Cyclin-A2, CCNA2, CCN1, Cyclin-A, CCNA)
124485CCNT1 (Cyclin T1, Cyclin-T1, CycT1, Cyclin-T)
301337-FITCCyclin E1 (Cyclin-E1) (FITC)
C8452-71BCyclin A1 (Cyclin-A1, CCNA1)
124473CCNA1 (Cyclin A1, Cyclin-A1)

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