CD45RB

• Gene Name:

  [PTPRC]

• NCBI Gene ID:

  5788

• Reactivity:

  Human. Does not react with rat and rhesus monkey.

• Storage Conditions:

  Store at 2 to 8 °C. Antibody is stable for 24 months.

• Specificity:

  CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

• Other Gene Names:

  [PTPRC; PTPRC; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; CD45; L-CA]

• Short Name:

  [CD45RB]

• Other Product Names:

  [receptor-type tyrosine-protein phosphatase C isoform 1; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide; protein tyrosine phosphatase, receptor type, C; Leukocyte common antigen; L-CA; T200; CD_antigen: CD45]

• NCBI GI Number:

  392307007

• NCBI Accession Number:

  NP_002829.3

• NCBI GB Accession Number:

  NM_002838.4

• Uniprot Accession Number:

  P08575