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OSI-930

CAT: 0013-GTR19173670-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173670-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OSI-930 is an orally bioavailable small molecule dual inhibitor of c-Kit and VEGFR-2 tyrosine kinases. It is used in cancer research to study mechanisms of tumor cell proliferation and angiogenesis, with applications in both in vitro assays and in vivo xenograft models.
CAS Number
728033-96-3
Product Name Alternative
Apoptosis, antitumor, C-Raf, CSF-1 receptor, CSF1R, CSF-1R, colony stimulating factor 1 receptor, cKit, c-Kit, cFms, c-Fms, CD117, OSI 930, OSI930, OSI-930, inhibit, Inhibitor, Lck, FLT1, selective, SCFR, Vascular endothelial growth factor receptor, VEGFR, VEGFR2 (KDR)
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.67% (May vary between batches)
Solubility
DMSO:82 mg/mL (184.92 mM) ; Ethanol:3 mg/mL (6.77 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.44 mM)
Smiles
FC (F) (F) Oc1ccc (NC (=O) c2sccc2NCc2ccnc3ccccc23) cc1
Molecular Formula
C22H16F3N3O2S
Molecular Weight
443.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Osi-930

3-(4-quinolinylmethylamino)-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide is an aromatic amide.

CAS Number728033-96-3
PubChem CID9868037
IUPAC Name3-(quinolin-4-ylmethylamino)-N-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxamide
Molecular FormulaC22H16F3N3O2S
Molecular Weight443.4
XLogP6.2
Topological Polar Surface Area91.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity601
SMILES
C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F
InChI
InChI=1S/C22H16F3N3O2S/c23-22(24,25)30-16-7-5-15(6-8-16)28-21(29)20-19(10-12-31-20)27-13-14-9-11-26-18-4-2-1-3-17(14)18/h1-12,27H,13H2,(H,28,29)
InChIKey
FGTCROZDHDSNIO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Osi-930
CAS: 728033-96-3
CID: 9868037
Formula: C22H16F3N3O2S
MW: 443.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.4
XLogP36.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass443.09153242
Monoisotopic Mass443.09153242
Topological Polar Surface Area91.5 Ų
Heavy Atom Count31
Formal Charge0
Complexity601
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1712-5OSI-930
MBS575928OSI 930

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