p53 Tumor Suppressor Protein Mouse Monoclonal Antibody

• Gene Name:

  [TP53]

• NCBI Gene ID:

  7157

• Reactivity:

  Human, Monkey, Cow.
  Others not known

• Storage Conditions:

  Antibody with azide - store at 2-8°C.
  Antibody is stable for 24 months. Non-hazardous.

• Specificity:

  Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

• Other Gene Names:

  [TP53; TP53; P53; BCC7; LFS1; TRP53; P53]

• Short Name:

  [p53 Tumor Suppressor Protein]

• Other Product Names:

  [cellular tumor antigen p53 isoform a; Cellular tumor antigen p53; cellular tumor antigen p53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53]

• NCBI GI Number:

  120407068

• NCBI Accession Number:

  NP_000537.3

• NCBI GB Accession Number:

  NM_000546.5

• Uniprot Accession Number:

  P04637

• CAS Number:

  9007-83-4