Rb1 (Tumor Suppressor Protein)

• Gene Name:

  [Rb1]

• NCBI Gene ID:

  5925

• Reactivity:

  Human, Mouse. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

• Other Gene Names:

  [RB1; RB1; RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; Rb]

• Short Name:

  [Rb1]

• Other Product Names:

  [retinoblastoma-associated protein; Retinoblastoma-associated protein; retinoblastoma-associated protein; RB transcriptional corepressor 1; p105-Rb; pRb; Rb; pp110]

• NCBI GI Number:

  108773787

• NCBI Accession Number:

  NP_000312.2

• NCBI GB Accession Number:

  NM_000321.2

• Uniprot Accession Number:

  P06400