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Nicardipine

CAT: 0013-GTR19173551-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19173551-02Size:1 ml x 10 mM (in DMSO)
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Description
Nicardipine is a dihydropyridine calcium channel blocker used in research to study hypertension and angina. It is widely applied in cardiovascular research, serving as a key pharmacological tool for in vitro and in vivo investigations of vascular smooth muscle contraction and calcium signaling pathways.
CAS Number
55985-32-5
Product Name Alternative
Dagan, CalciumChannel, Ca2+ channels, Ca channels, calcium channel, Calcium Channel, cardiac, Cardene, blood, blocker, Antagonil, angina, Flusemide, Inhibitor, inhibit, Nicardipine, YC93, YC-93, YC 93, pressure
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.56% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.17 mM) ; DMSO:250 mg/mL (521.35 mM)
Smiles
COC (=O) C1=C (C) NC (C) =C (C1c1cccc (c1) [N+] ([O-]) =O) C (=O) OCCN (C) Cc1ccccc1
Molecular Formula
C26H29N3O6
Molecular Weight
479.52
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Nicardipine

Nicardipine is a racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. It has a role as a vasodilator agent, an antihypertensive agent, a calcium channel blocker and an autophagy inhibitor. It contains a (S)-nicardipine and a (R)-nicardipine.

CAS Number55985-32-5
PubChem CID4474
IUPAC Name5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Molecular FormulaC26H29N3O6
Molecular Weight479.5
XLogP3.8
Topological Polar Surface Area114
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count10
Heavy Atom Count35
Formal Charge0
Complexity856
SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
InChI
InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
InChIKey
ZBBHBTPTTSWHBA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nicardipine
CAS: 55985-32-5
CID: 4474
Formula: C26H29N3O6
MW: 479.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight479.5
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count10
Exact Mass479.20563565
Monoisotopic Mass479.20563565
Topological Polar Surface Area114 Ų
Heavy Atom Count35
Formal Charge0
Complexity856
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T21454-01Nicardipine
B1798-5000Nicardipine HCl
T1215-01Nicardipine hydrochloride
ALX-550-273-G005Nicardipine . hydrochloride
MBS5767552(S)-Nicardipine

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