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Carbidopa monohydrate

CAT: 0013-GTR19174479-03Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174479-03Size:500 mg
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Description
Carbidopa monohydrate is a selective DOPA decarboxylase inhibitor used in research to block the peripheral conversion of levodopa to dopamine. It is a key tool in neuroscience and pharmacology for modeling Parkinson's disease and studying dopaminergic pathways in both in vitro and in vivo experimental systems.
CAS Number
38821-49-7
Product Name Alternative
AhR, cancer, Carbidopa, Carbidopa Hydrate, Carbidopa Monohydrate, Carbidopa monohydrate, ArylHydrocarbonReceptor, Aryl Hydrocarbon Receptor, aromatic-L-amino-acid decarboxylase, disease, Inhibitor, Parkinson's, pancreatic, inhibit, peripheral, SCarbidopa, S (-) -Carbidopa
Field of Research
Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery
Purity
98.11% (May vary between batches)
Solubility
DMSO:5.5 mg/mL (22.52 mM)
Smiles
CC (CC1=CC=C (O) C (O) =C1) (NN) C (O) =O
Molecular Formula
C10H16N2O5
Molecular Weight
244.24
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Carbidopa monohydrate

Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an antiparkinson drug, a dopaminergic agent, an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor and an antidyskinesia agent. It is a member of hydrazines, a monocarboxylic acid, a member of catechols and a hydrate. It contains a carbidopa (anhydrous).

CAS Number38821-49-7
PubChem CID38101
IUPAC Name(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;hydrate
Molecular FormulaC10H16N2O5
Molecular Weight244.24
Topological Polar Surface Area117
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity261
SMILES
C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN.O
InChI
InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
InChIKey
QTAOMKOIBXZKND-PPHPATTJSA-N
Chemical Structure
2D Structure
2D structure of Carbidopa monohydrate
CAS: 38821-49-7
CID: 38101
Formula: C10H16N2O5
MW: 244.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight244.24
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass244.10592162
Monoisotopic Mass244.10592162
Topological Polar Surface Area117 Ų
Heavy Atom Count17
Formal Charge0
Complexity261
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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