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AG1557

CAT: 0013-GTR19173406-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173406-04Size:50 mg
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Description
AG1557 is a potent and selective EGFR tyrosine kinase inhibitor with a pIC50 of 8.194. This small molecule is used in biochemical and cellular assays to study EGFR-driven signaling pathways in cancer research, including investigations into cell proliferation and tumor growth.
CAS Number
189290-58-2
Product Name Alternative
Inhibit, EGFR, Epidermal growth factor receptor, ErbB-1, Inhibitor, HER1, hERG, AG 1557, AG1557, AG-1557
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.46 mM) ; DMSO:4.08 mg/mL (10.02 mM)
Smiles
COc1cc2ncnc (Nc3cccc (I) c3) c2cc1OC
Molecular Formula
C16H14IN3O2
Molecular Weight
407.21
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(3-Iodophyenyl)-6,7-dimethoxyoxy-4-quinazolina
CAS Number189290-58-2
PubChem CID5328201
IUPAC NameN-(3-iodophenyl)-6,7-dimethoxyquinazolin-4-amine
Molecular FormulaC16H14IN3O2
Molecular Weight407.21
XLogP4
Topological Polar Surface Area56.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity360
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)I)OC
InChI
InChI=1S/C16H14IN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChIKey
FGCLAQLIXMAIHT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-Iodophyenyl)-6,7-dimethoxyoxy-4-quinazolina
CAS: 189290-58-2
CID: 5328201
Formula: C16H14IN3O2
MW: 407.21
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight407.21
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass407.01307
Monoisotopic Mass407.01307
Topological Polar Surface Area56.3 Ų
Heavy Atom Count22
Formal Charge0
Complexity360
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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